Miscarriage with a normal embryo is devastating, but it may point to underlying factors IVF can’t address.

By understanding these issues, you can move away from repeated disappointment and find success with a strategic option like gestational surrogacy.

Are you ready to get closer to your path to parenthood? Connect with a specialist at American Surrogacy today to explore a proven path forward.

The Heartbreak of Hope: Experiencing Miscarriages with Genetically Tested Embryos

The journey to parenthood after facing recurrent pregnancy loss is profoundly difficult. After investing so much in IVF and creating an embryo, receiving news of another miscarriage feels devastating and deeply confusing.

This experience is not a failure on your part, but a sign that the focus needs to shift.

You have faced setbacks beyond your control, but by choosing surrogacy, you are giving your embryos the best opportunity.

Normal Embryos Don’t Guarantee a Successful Pregnancy

Preimplantation Genetic Testing (PGT-A) is an invaluable diagnostic tool in modern IVF. It allows your medical team to check an embryo’s chromosome count before transfer.

An embryo confirmed as “euploid” (or chromosomally normal) has the correct number of chromosomes and is considered the highest quality embryo available.

However, PGT-A does not guarantee pregnancy. A chromosomally normal embryo does not override underlying systemic or uterine health issues within the intended mother’s body.

Hidden Causes of IVF Miscarriages with Normal Embryos: Uterine, Hormonal, and Immune Factors

Recurrent implantation failure or miscarriage with a normal embryo points toward factors that cannot be solved by simply creating another embryo.

These issues are often subtle, requiring specific diagnostic testing and sometimes a change in approach.

Uterine Environment Factors

The endometrium, the lining of the uterus, must be receptive and healthy. Issues in this area can prevent implantation or lead to early loss:

• Endometrial Thickness and Structure: A lining that is too thin, uneven, or structurally abnormal may fail to properly support the embryo. Your doctor may refer to this as a lack of uterine receptivity.
• Endometriosis and Adenomyosis: These common, inflammatory conditions can create a hostile environment that makes implantation and sustained pregnancy extremely difficult.
• Chronic Endometritis (CE): This is a persistent, non-symptomatic inflammation of the endometrial lining, often caused by an underlying bacterial infection.
• Structural Abnormalities: Unidentified polyps, fibroids, or scar tissue (Asherman’s Syndrome) can obstruct implantation or compromise the blood supply necessary for the placenta’s development.

Learn more about uterine health issues that may be making pregnancy impossible.

Autoimmune or Chronic Health Factors

In some cases, the body’s immune system is the barrier. The body may treat the embryo as a foreign object and reject it.

Autoimmune or inflammatory conditions that are not properly managed can create a highly inflamed environment in the body that prevents a pregnancy from starting or growing. These include:

• Lupus: A chronic autoimmune disease that can increase the risk of blood clotting and inflammation, compromising the blood flow needed for the placenta.
• Multiple Sclerosis (MS): While generally not a direct barrier to conception, severe or active MS can indicate systemic inflammation that impacts the immune environment needed for implantation.
• Hashimoto’s Thyroiditis: An autoimmune thyroid condition often linked to recurrent miscarriage, as unmanaged thyroid hormones are essential for successful early pregnancy development.
• PCOS (Polycystic Ovary Syndrome): While primarily hormonal, it often involves chronic, low-grade inflammation that can negatively affect uterine receptivity and embryo implantation.
• Natural Killer (NK) Cells: While complex and often debated, some specialists believe an overactive presence of these immune cells in the uterus may attack the implanting embryo, treating it as a foreign object.

Learn more about chronic health conditions that may make pregnancy difficult or unsafe.

Hormonal and Timing Factors

Issues with hormones and timing are another barrier to successful implantation.

The uterine lining has a very narrow “window of implantation”, meaning the timing of the embryo transfer must be exact, even with standard hormone medication.

 Specialized tests like the Endometrial Receptivity Assay (ERA) help pinpoint this timing, but repeated failure suggests the window is consistently missed or compromised.

Additionally, a lack of sufficient natural progesterone during the early weeks, known as luteal phase support, can still compromise the lining’s ability to sustain the pregnancy, leading to loss

When to Consider Surrogacy After Multiple Miscarriages with Test Embryos

This decision should be made in consultation with your reproductive endocrinologist.

However, clear emotional and medical triggers often indicate surrogacy is the next strategic step:

• Specific medical barriers. You have received a confirmed diagnosis that your medical team identifies as the primary cause of recurrent loss.
• Your mental health has taken a toll. Surrogacy offers a way to continue the family-building process without the constant physical and emotional strain of repeated failures.
• The cumulative cost of repeated IVF cycles, specialized testing, and experimental treatments may become unsustainable. Surrogacy provides a more predictable investment toward achieving your family goal.
• You have remaining embryos. If you have frozen PGT-tested embryos, using them with a gestational carrier gives them the highest possible chance.

Surrogacy is not a last resort; it is a strategic, medically supported path to success when evidence points to the uterine environment as the barrier.

How Surrogacy Bypasses Uterine Factors That IVF Can’t Solve

When you choose American Surrogacy, we build your journey on the foundation of a thoroughly vetted and medically cleared gestational carrier.

This process is designed to eliminate the gamble of an unpredictable uterine environment and maximize the possibility of a healthy pregnancy.

Our rigorous, multi-step screening ensures you start your journey with confidence:

• Agency Review: We start with an in-depth review of her full medical history and social background.
• Clinic Review: Your fertility clinic reviews her past medical records, focusing on previous pregnancies and deliveries, to confirm a history of successful, healthy births.
• Medical Clearance and Physical Exam: She undergoes a comprehensive physical examination and medical workup at your fertility clinic to confirm her uterus is optimally receptive and structurally sound for a successful transfer and pregnancy.

Other essential clearances we ensure include:

• Psychological Readiness: Confirming she is emotionally and mentally prepared for the journey and understands the unique relationship with you.

By utilizing a gestational carrier who has been carefully and successfully screened through these multiple layers of review, you replace anxiety with certainty, knowing your precious embryo is in the safest possible environment.

Emotional Healing and Moving Forward

The grief, fatigue, and profound sense of failure that accompany recurrent loss are entirely understandable. Even when you know the miscarriage was not your fault, the emotional burden is real.

Surrogacy offers a crucial opportunity for psychological recovery and consciously moving forward with your family-building journey.

Gaining Control: Making an Intentional Choice for Family

Instead of dwelling on past disappointments, surrogacy allows you to pivot your focus on creating your family.

• Move from Strain to Preparation: Surrogacy allows you to move past the physical burden and psychological toll of recurrent IVF failure. You can channel the energy previously spent on treatments into preparing for the baby’s arrival.
• Taking Control: Instead of passively waiting for a diagnostic test or an experimental treatment, you are actively choosing the most successful, medically supported path available to you.
• A Supported Journey: At American Surrogacy, we provide comprehensive support so you can focus on your path to parenthood.

What to Expect When Exploring Surrogacy as a Next Step

The idea of starting the surrogacy process can feel overwhelming, but our agency is here to simplify every step. We offer a clear, efficient path designed to minimize stress and maximize success:

Step 1: Reach Out to a Specialist

Your first step is connecting with a specialist at American Surrogacy. We listen to your unique story, understand your medical history, and help you determine if our program is the right fit.

Step 2: Match with a Surrogate

Based on your preferences, we present you with profiles of pre-screened, medically cleared gestational carriers. Our focused process often leads to quick matches.

Step 3: Complete Legal Contracts

Attorneys work together to create comprehensive, protective legal agreements that establish your parentage.

Step 4: Embryo Transfer

Your reproductive endocrinologist facilitates the transfer of your PGT-tested embryo to the gestational carrier. We support you throughout the entire medical process.

Step 5: Pregnancy and Birth

You remain closely involved throughout the pregnancy, preparing for the day you welcome your child at the hospital.

Ready to Take the Next Step? Explore Surrogacy with Compassion and Clarity

You have faced setbacks beyond your control, but by choosing the strategic path of surrogacy, you are giving your embryos the best opportunity for success.

Surrogacy is not a detour; it is a supported, deliberate choice made by loving parents who refuse to give up on their family dream.

Even with multiple miscarriages, you can still start or grow your family. Contact us to learn how we can support you on your path to parenthood.